Canine neuronal ceroid lipofuscinoses: Promising models for preclinical testing of therapeutic interventions

Abstract excerpt

The neuronal ceroid lipofuscinoses (NCLs) are devastating inherited progressive neurodegenerative diseases, with most forms having a childhood onset of clinical signs. The NCLs are characterized by progressive cognitive and motor decline, vision loss, seizures, respiratory and swallowing impairment, and ultimately premature death. Different forms of NCL result from mutations in at least 13 genes. The clinical...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Carbohydrate Chemistry and Synthesis
• Share to Glycosylation and Glycoproteins Research
• Share to Lysosomal Storage Disorders Research