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Article

Only rare classical MHC-I alleles are highly expressed in the European house sparrow.

Proceedings. Biological sciences - 28 Feb 2024

Watson Hannah, Drews Anna, Skogsmyr Kelly Hultman, Neto Júlio Manuel, Roved Jacob, Westerdahl Helena

Abstract excerpt

The exceptional polymorphism observed within genes of the major histocompatibility complex (MHC), a core component of the vertebrate immune system, has long fascinated biologists. The highly polymorphic classical MHC class-I (MHC-I) genes are maintained by pathogen-mediated balancing selection (PMBS), as shown by many sites subject to positive selection, while the more monomorphic non-classical MHC-I genes show...

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Identifiers

PMID: 38378156
DOI: 10.1098/rspb.2023.2857
PMCID: PMC10878800

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