Article
Occurrence of Existing BCR-ABL Baseline Mutations and Associated Haplotype (NmR) Among CML Patients with Diverse IM Response: A Hospital-based Study from North-East India.
Biochemical genetics - 1 Dec 2024
Hazarika Gautam, Kalita Manash Jyoti, Das Partha Pratim, Kalita Simanta, Dutta Kalpajit, Lahkar Lipika, Rajkonwar Anjanjyoti, Idris Mohammed Ghaznavi, Khamo Vinotsale, Kusre Giriraj, Medhi Subhash
Abstract excerpt
Highly polymorphic BCR-ABL kinase domains have been reported to harbor more than a hundred mutations, and among these, 40-60% have been identified as influencers of imatinib mesylate (IM) resistance. The emergence of IM resistance poses a significant challenge in the management of Chronic Myeloid Leukemia (CML). M351T (rs121913457), E255K (rs387906517), and Y253H (rs121913461) are of particular clinical...
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