Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Manufacturing Cell and Gene Therapies: Challenges in Clinical Translation

16 Feb 2024

Abstract excerpt

The safety and efficacy of both cell and gene therapies have been demonstrated in numerous preclinical and clinical trials. Chimeric antigen receptor T (CAR-T) cell therapy, which leverages the technologies of both cell and gene therapies, has also shown great promise for treating various cancers. Advancements in pertinent fields have also highlighted challenges faced while manufacturing cell and gene therapy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to CRISPR and Genetic Engineering
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38361427
DOI: 10.3343/alm.2023.0382

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Manufacturing Cell and Gene Therapies: Challenges in Clinical TranslationPMID 38361427Read ↗

GMP manufacturing of cell and gene therapy products: Challenges, opportunities, and pathways forwardSemantic proximity Read ↗

Revolutionizing CAR T Cell Therapies: Innovations in Genetic Engineering and Manufacturing to Enhance Efficacy and AccessibilitySemantic proximity Read ↗

Gene therapy: challenges in cell culture scale-upSemantic proximity Read ↗

Critical challenges and advances in recombinant adeno‐associated virus (rAAV) biomanufacturingSemantic proximity Read ↗

Considerations for manufacturing of cell and gene medicines for clinical developmentSemantic proximity Read ↗

Towards a commercial process for the manufacture of genetically modified T cells for therapySemantic proximity Read ↗

Development of Cell and Gene Therapies for Clinical Use in the US and EU: Summary of Regulatory GuidelinesSemantic proximity Read ↗

Scaling up and scaling out: Advances and challenges in manufacturing engineered T cell therapiesSemantic proximity Read ↗

Viral vector manufacturing: how to address current and future demands?Semantic proximity Read ↗

Definition and application of good manufacturing process-compliant production of CEA-specific chimeric antigen receptor expressing T-cells for phase I/II clinical trialSemantic proximity Read ↗

Global Manufacturing of CAR T Cell TherapySemantic proximity Read ↗

Manufacturing of viral vectors for gene therapy: part I. Upstream processingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.