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Article

Nairovirus polymerase mutations associated with the establishment of persistent infection in human cells.

Journal of virology - 19 Mar 2024

Ohta Keisuke, Saka Naoki, Nishi Yuzuha, Nishio Machiko

Abstract excerpt

Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne virus of the Orthonairovirus genus, persistently infects tick cells. It has been reported to establish persistent infection in non-human primates, but virological analysis has not yet been performed in human cells. Here, we investigated whether and how nairoviruses persistently infect human cells using Hazara orthonairovirus (HAZV), a surrogate model for...

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Identifiers

PMID: 38358288
DOI: 10.1128/jvi.01698-23
PMCID: PMC10949423

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