Causal relationship between gut microbiome and sex hormone‐binding globulin: A bidirectional two‐sample Mendelian randomization study

Abstract excerpt

Abstract Problem Currently, there is a variety of evidence linking the gut microbiota to changes in sex hormones. In contrast, the causal relationship between SHBG, a carrier of sex hormones, and the gut microbiota is unclear. Method of Study Bidirectional two‐sample Mendelian randomization (MR) analysis was used to detect the causal effect between SHBG and the gut microbiome. Summary statistics of genome‐wide...

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