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Article

Stromal-derived MAOB promotes prostate cancer growth and progression

9 Feb 2024

Abstract excerpt

Prostate cancer (PC) develops in a microenvironment where the stromal cells modulate adjacent tumor growth and progression. Here, we demonstrated elevated levels of monoamine oxidase B (MAOB), a mitochondrial enzyme that degrades biogenic and dietary monoamines, in human PC stroma, which was associated with poor clinical outcomes of PC patients. Knockdown or overexpression of MAOB in human prostate stromal...

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PMID: 38335292
DOI: 10.1126/sciadv.adi4935

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