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Article

Mutation of conserved histidine residues of dengue virus envelope protein impairs viral like particle maturation and secretion.

Biochimica et biophysica acta. Molecular cell research - 1 Mar 2024

Rani N Veena, Baig Mirza Sarwar, Pathak Bharti, Kapoor Neera, Krishnan Anuja

Abstract excerpt

Dengue virus (DENV) envelope protein plays crucial role in virus entry and maturation of virus during infection. Maturation of DENV occurs in the trans Golgi network at slightly acidic pH which is close to pKa of histidine. When exposed to the acidic environment of the late secretory pathway, dengue virus particles go through a significant conformational change, whereby interactions of structural proteins...

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PMID: 38301907
DOI: 10.1016/j.bbamcr.2024.119682

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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