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Aging as a Consequence of the Adaptation–Maladaptation Dilemma

1 Feb 2024

Abstract excerpt

In aging, the organism is unable to counteract certain harmful influences over its lifetime which leads to progressive dysfunction and eventually death, thus delineating aging as one failed process of adaptation to a set of aging stimuli. A central problem in understanding aging is hence to explain why the organism cannot adapt to these aging stimuli. The adaptation-maladaptation theory of aging proposes that in...

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PMID: 38299389
DOI: 10.1002/adbi.202300654

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