Context-dependent effects of MIR100HG on tumorigenic phenotypes and p38/MAPK-AKT signaling in hepatocellular carcinoma.

doi:10.1007/s10142-026-02033-5

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Context-dependent effects of MIR100HG on tumorigenic phenotypes and p38/MAPK-AKT signaling in hepatocellular carcinoma.

Functional & integrative genomics - 5 Sept 2026

Tokay Esra, Koc Sevin Avsar, Dulger Aylin Turkoglu, Alacam Rümeysa, Hacioglu Nelin, Alper Meltem, Kockar Feray

Abstract excerpt

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide and is characterized by a hypoxic tumor microenvironment that promotes tumor progression, cellular adaptation, and therapeutic resistance. Increasing evidence indicates that long non-coding RNAs (lncRNAs) play critical roles in regulating tumor-associated signaling networks; however, the contribution of MIR100HG to...

Read the complete abstract on PubMed

Topics

Humans
Liver Neoplasms
Carcinoma, Hepatocellular
Proto-Oncogene Proteins c-akt
Cell Line, Tumor
p38 Mitogen-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

MicroRNAs

Gene Expression Regulation, Neoplastic

Cell Proliferation

Signal Transduction

Carcinogenesis

Cell Movement

MAP Kinase Signaling System

RNA, Long Noncoding

Phenotype

Source

Open in PubMed

Identifiers

PMID: 42698010
DOI: 10.1007/s10142-026-02033-5

Genes

GAS6
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Context-dependent effects of MIR100HG on tumorigenic phenotypes and p38/MAPK-AKT signaling in hepatocellular carcinoma.PMID 42698010Read ↗

LINC00839 is associated with hypoxia-related malignant phenotypes in hepatocellular carcinomaSemantic proximity Read ↗

LncRNA MIR205HG accelerates cell proliferation, migration and invasion in hepatoblastoma through the activation of MAPK signaling pathway and PI3K/AKT signaling pathwaySemantic proximity Read ↗

Long noncoding RNA SNHG4 promotes the malignant progression of hepatocellular carcinoma through the miR ‐211‐5p/ CREB5 axisSemantic proximity Read ↗

Epigenetic silencing of tumor suppressor gene CDKN1A by oncogenic long non-coding RNA SNHG1 in cholangiocarcinomaSemantic proximity Read ↗

Dysregulation of MicroRNAs in Hepatocellular Carcinoma: Targeting Oncogenic Signaling Pathways for Innovative TherapiesSemantic proximity Read ↗

Long non-coding RNA GAS5, by up-regulating PRC2 and targeting the promoter methylation of miR-424, suppresses multiple malignant phenotypes of glioma.Semantic proximity Read ↗

LncRNA SNHG17 Contributes to Proliferation, Migration, and Poor Prognosis of Hepatocellular CarcinomaSemantic proximity Read ↗

Emerging Signaling Pathways in Hepatocellular CarcinomaSemantic proximity Read ↗

LncRNA SNHG3 Facilitates the Malignant Phenotype of Cholangiocarcinoma Cells via the miR-3173-5p/ERG Axis.Semantic proximity Read ↗

Long noncoding RNA SNHG6 promotes proliferation and angiogenesis of cholangiocarcinoma cells through sponging miR-101-3p and activation of E2F8Semantic proximity Read ↗

PRR34-AS1 sponges miR-498 to facilitate TOMM20 and ITGA6 mediated tumor progression in HCCSemantic proximity Read ↗

Enhanced expression of lncRNA TP73-AS1 predicts adverse phenotypes for cholangiocarcinoma and exerts oncogenic properties in vitro and in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.