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Glomerular spatial transcriptomics of IgA nephropathy according to the presence of mesangial proliferation

26 Jan 2024

Abstract excerpt

Mesangial proliferation is a diagnostic feature and a prognostic predictor of immunoglobulin A nephropathy (IgAN). We aimed to investigate the gene expression profiles of IgAN glomerulus according to the presence of mesangial proliferation. We performed spatial-specific transcriptomic profiling on kidney biopsy tissues using the GeoMx Digital Spatial Profiler. Twelve cases with three glomeruli for each case were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38278877
DOI: 10.1038/s41598-024-52581-8

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