Article
Cell-free DNA levels associate with COPD exacerbations and mortality.
Respiratory research - 18 Jan 2024
Ware Sarah A, Kliment Corrine R, Giordano Luca, Redding Kevin M, Rumsey William L, Bates Stewart, Zhang Yingze, Sciurba Frank C, Nouraie S Mehdi, Kaufman Brett A
Abstract excerpt
THE QUESTION ADDRESSED BY THE STUDY: Good biological indicators capable of predicting chronic obstructive pulmonary disease (COPD) phenotypes and clinical trajectories are lacking. Because nuclear and mitochondrial genomes are damaged and released by cigarette smoke exposure, plasma cell-free mitochondrial and nuclear DNA (cf-mtDNA and cf-nDNA) levels could potentially integrate disease physiology and clinical...
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