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Article

Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort

2 Jan 2020

Abstract excerpt

BACKGROUNDMitochondrial dysfunction, a proposed mechanism of chronic obstructive pulmonary disease (COPD) pathogenesis, is associated with the leakage of mitochondrial DNA (mtDNA), which may be detected extracellularly in various bodily fluids. Despite evidence for the increased prevalence of chronic kidney disease in COPD subjects and for mitochondrial dysfunction in the kidneys of murine COPD models, whether...

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PMID: 31895696
DOI: 10.1172/jci.insight.133984

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