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Article

Development of PARP inhibitors in advanced prostate cancer

1 Jan 2024

Abstract excerpt

The relatively high prevalence of alterations in the homologous recombination repair (HRR) pathway described in advanced prostate cancer provides a unique opportunity to develop therapeutic strategies that take advantage of the decreased tumor ability to repair DNA damage. Poly ADP-ribose polymerase (PARP) inhibitors have been demonstrated to improve the outcomes of metastatic castration-resistant prostate cancer...

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PMID: 38205078
DOI: 10.1177/17588359231221337

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