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Article

Mimicking TGFBI Hot-Spot Mutation Did Not Result in Any Deposit Formation in the Zebrafish Cornea.

Current eye research - 1 May 2024

Yaylacıoğlu Tuncay Fulya, Talim Beril, Dinçer Pervin Rukiye

Abstract excerpt

PURPOSE: Mutations in transforming growth factor beta-induced (TGFBI) protein are associated with a group of corneal dystrophies (CDs), classified as TGFBI-associated CDs, characterized by deposits in the cornea. Mouse models were not proper in several aspects for modelling human disease. The goal of this study was to generate zebrafish mutants to investigate the corneal phenotype and to decide whether zebrafish...

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Share to Cornea
Share to Corneal Dystrophies, Hereditary
Share to Corneal Opacity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Extracellular Matrix Proteins

Share to RNA, Guide, CRISPR-Cas Systems

Share to Transforming Growth Factor beta

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Source

Identifiers

PMID: 38164916
DOI: 10.1080/02713683.2023.2298904

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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