Article
Low dose ribosomal DNA P-loop mutation affects development and enforces autophagy in Arabidopsis.
RNA biology - 1 Jan 2024
Shanmugam Thiruvenkadam, Chaturvedi Palak, Streit Deniz, Ghatak Arindam, Bergelt Thorsten, Simm Stefan, Weckwerth Wolfram, Schleiff Enrico
Abstract excerpt
Arabidopsis contains hundreds of ribosomal DNA copies organized within the nucleolar organizing regions (NORs) in chromosomes 2 and 4. There are four major types of variants of rDNA, VAR1-4, based on the polymorphisms of 3' external transcribed sequences. The variants are known to be differentially expressed during plant development. We created a mutant by the CRISPR-Cas9-mediated excision of ~ 25 nt from...
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