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Article

Identification of novel aminopyrimidine derivatives for the treatment of mutant NSCLC.

European journal of medicinal chemistry - 5 Feb 2024

Hu Liping, Shi Shengmin, Song Xiaomeng, Ma Fangli, Ji Oulian, Qi Baohui

Abstract excerpt

Starting from the binding mode of allosteric EGFR inhibitor JBJ-04-125-02 and the key pharmacophore of the third-generation EGFR inhibitors, we designed and synthesized a novel series of EGFR inhibitors, represented by (R)-N-(4-((2-aminopyrimidin-4-yl)amino)phenyl)-2-(5-(4-(4-methylpiperazin-1-yl)phenyl)-1-oxoisoindolin-2-yl)-2-phenylacetamide (6q). Docking study demonstrated that top compound 6q spanned...

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Source

Identifiers

PMID: 38142512
DOI: 10.1016/j.ejmech.2023.116074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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