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Article

In vivo base editing rescues primary hyperoxaluria type 1 in rats.

Kidney international - 1 Mar 2024

Chen Zhoutong, Zhang Dexin, Zheng Rui, Yang Lei, Huo Yanan, Zhang Dan, Fang Xiaoliang, Li Yueyan, Xu Guofeng, Li Dali, Geng Hongquan

Abstract excerpt

Primary hyperoxaluria type 1 (PH1) is a childhood-onset autosomal recessive disease, characterized by nephrocalcinosis, multiple recurrent urinary calcium oxalate stones, and a high risk of progressive kidney damage. PH1 is caused by inherent genetic defects of the alanine glyoxylate aminotransferase (AGXT) gene. The in vivo repair of disease-causing genes was exceedingly inefficient before the invention of base...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38142039
DOI: 10.1016/j.kint.2023.11.029

Genes

AGT
AGXT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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