Article
VEXAS syndrome: a comprehensive clinicopathologic and genetic analysis of a predominantly Indian cohort.
Journal of hematopathology - 16 May 2026
Chinnam Dheeraj, Kerkar Aadya, Gulati Rohit, Bhatia Prateek, Sreedharanunni Sreejesh, Sharma Praveen, Singh Minu, Shah Shikha, Baskaran Narayanan, Puligari Ramya, Ganju Neha Avtarkrishan, Mruthyunjaya Prakashini, K S Lekshmon, Bishnoi Anuradha, De Dipanker, Veeravalli Sarath Chandra Mouli, Khushoo Vishvdeep, Ganju Avtar Krishan, Padhan Prasanta, Antony Paul, Gupta Vikas, Balakrishnan Anand, Sharma Arushi, Gupta Dikshat Gopal, Sharma Aman, Malhotra Pankaj
Abstract excerpt
BACKGROUND: VEXAS syndrome is a recently recognized, acquired monogenic adult onset hemato-inflammatory syndrome characterized by somatic mutations within the UBA1 gene. The acronym VEXAS stands for vacuoles, E1 enzyme, X-linked inheritance, autoinflammatory tendencies, and somatic mutations. It presents as a severe progressive disease displaying varied characteristics that bridge hematologic and rheumatologic...
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