Article
Poly-omic risk scores predict inflammatory bowel disease diagnosis.
mSystems - 23 Jan 2024
Arehart Christopher H, Sterrett John D, Garris Rosanna L, Quispe-Pilco Ruth E, Gignoux Christopher R, Evans Luke M, Stanislawski Maggie A
Abstract excerpt
Inflammatory bowel disease (IBD) is characterized by complex etiology and a disrupted colonic ecosystem. We provide a framework for the analysis of multi-omic data, which we apply to study the gut ecosystem in IBD. Specifically, we train and validate models using data on the metagenome, metatranscriptome, virome, and metabolome from the Human Microbiome Project 2 IBD multi-omic database, with 1,785 repeated...
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