Article
Understanding the Impact of Population and Cancer Type on Tumor Mutation Burden Scores: A Comprehensive Whole-Exome Study in Cancer Patients From India.
JCO global oncology - 1 Sept 2023
Tanwar Nishtha AjitSingh, Malhotra Richa, Satheesh Aiswarya Padmaja, Khuntia Satya Prakash, Sreekanthreddy Peddagangannagari, Varghese Linu, Kolla Srivalli, Chandrani Pratik, Choughule Anuradha, Pange Priyanka, Gupta Vinod, Noronha Vanita, Patil Vijay Maruti, Pramanik Raja, Kumar Sunila, Nayak Sandeep Peraje, Babu Suresh, Shetty Rohan, Kantharaju Madan, Chinder Pramod Shekarappa, Korlimarla Aruna, Srinath B S, Prabhash Kumar, Rishi Kshitij Datta, Goswami Hitesh Madan, Veldore Vidya Harini
Abstract excerpt
PURPOSE: The purpose of this study was to understand the impact of population diversity and geographic variation on tumor mutation burden (TMB) scores across cancers and its implication on stratification of patients for immune checkpoint inhibitor (ICI) therapy. MATERIALS AND METHODS: This retrospective study used whole-exome sequencing (WES) to profile 1,233 Indian patients with cancer across 30 different cancer...
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