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Article

Exosome-mediated Delivery of miR-519e-5p Promotes Malignant Tumor Phenotype and CD8+ T-Cell Exhaustion in Metastatic PTC.

The Journal of clinical endocrinology and metabolism - 17 May 2024

Li Genpeng, Chen Wenjie, Jiang Ke, Huang Jing, Zhong Jinjing, Liu Xiaowei, Wei Tao, Gong Rixiang, Li Zhihui, Zhu Jingqiang, Shi Hubing, Lei Jianyong

Abstract excerpt

CONTEXT: Distant metastases are the primary cause of therapy failure and mortality in patients with papillary thyroid carcinomas (PTCs). However, the underlying mechanism responsible for the initiation of tumor cell dissemination and metastasis in PTCs has rarely been investigated. OBJECTIVE: The aim of this study was to investigate effects and underlying molecular mechanisms of circulating exosomal microRNAs...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Share to Thyroid Cancer, Papillary

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Source

Identifiers

PMID: 38078691
DOI: 10.1210/clinem/dgad725

Genes

NOTCH2
PLAGL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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