Article
Comprehensive molecular analysis identifies RET alterations association with response of ICIs in multi-immunotherapy cohorts.
International immunopharmacology - 5 Jan 2024
Long Jun-Yu, Li Rui-Zhe, Wang Dong-Xu, Liu Hui, Tian Jincheng, Ding Zi-Niu, Yan Lun-Jie, Dong Zhao-Ru, Hong Jian-Guo, Tian Bao-Wen, Han Cheng-Long, Zhao Hai-Tao, Li Tao
Abstract excerpt
BACKGROUND: The RET gene, which is frequently mutated across many types of cancer, has been proven to be critically involved in tumorigenesis and tumour development; however, its prediction of the therapeutic efficacy of immune checkpoint inhibitor (ICI) therapy remains to be elucidated. The present research aims to investigate the association between RET mutations and the efficiency of ICI therapy. METHOD: We...
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