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Clinical Benefit of Avapritinib in KIT-Mutant Gastrointestinal Stromal Tumors: A Post Hoc Analysis of the Phase I NAVIGATOR and Phase I/II CS3007-001 Studies.

Clinical cancer research : an official journal of the American Association for Cancer Research - 16 Feb 2024

Heinrich Michael C, Zhang Xinhua, Jones Robin L, George Suzanne, Serrano César, Deng Yanhong, Bauer Sebastian, Cai Shirong, Wu Xin, Zhou Yongjian, Tao Kaixiong, Zheng Zhichao, Zhang Jun, Cui Yuehong, Cao Hui, Wang Meining, Hu Jin, Yang Jason, Li Jian, Shen Lin

Abstract excerpt

PURPOSE: The efficacy of the selective KIT/PDGFRA inhibitor avapritinib (300 mg once daily) was explored in patients with non-PDGFRA-mutant gastrointestinal stromal tumors (GISTs) from the phase I NAVIGATOR and phase I/II CS3007-001 trials. PATIENTS AND METHODS: Adults with unresectable/metastatic, KIT-only-mutant GISTs and progression following ≥1 tyrosine kinase inhibitors (TKIs) were included in this post hoc...

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PMID: 38032349
DOI: 10.1158/1078-0432.CCR-23-1861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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