Article
Resistome and virulome of high-risk pandemic clones of multidrug-resistant extra-intestinal pathogenic Escherichia coli (ExPEC) isolated from tertiary healthcare settings in Uganda.
PloS one - 1 Jan 2023
Byarugaba Denis K, Erima Bernard, Wokorach Godfrey, Alafi Stephen, Kibuuka Hannah, Mworozi Edison, Musinguzi Ambrose K, Kiyengo James, Najjuka Florence, Wabwire-Mangen Fred
Abstract excerpt
Multi-drug resistant (MDR) globally disseminated extraintestinal pathogenic high-risk Escherichia coli (ExPEC) clones are threatening the gains in bacterial disease management. In this study, we evaluated the genomic structure including the resistome and virulome of the E. coli isolates from extraintestinal infections using whole genome sequencing (WGS). The results highlight that isolates were highly resistant...
Topics
- Humans
- Escherichia coli
- Extraintestinal Pathogenic Escherichia coli
- Escherichia coli Infections
- Tertiary Healthcare
- Uganda
- Pandemics
- Genotype
- Anti-Bacterial Agents