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Article

Structural insights into ACE2 interactions and immune activation of SARS-CoV-2 and its variants: an in-silico study.

Journal of biomolecular structure & dynamics - 1 Feb 2025

Yousefbeigi Sarina, Marsusi Farah

Abstract excerpt

The initial interaction between COVID-19 and the human body involves the receptor-binding domain (RBD) of the viral spike protein with the angiotensin-converting enzyme 2 (ACE2) receptor. Likewise, the spike protein can engage with immune-related proteins, such as toll-like receptors (TLRs) and pulmonary surfactant proteins A (SP-A) and D (SP-D), thereby triggering immune responses. In this study, we utilize...

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Share to Angiotensin-Converting Enzyme 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Pulmonary Surfactant-Associated Protein D

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Share to Spike Glycoprotein, Coronavirus

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Source

Identifiers

PMID: 37982275
DOI: 10.1080/07391102.2023.2283158

Genes

ACE2
TLR4
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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