Article
Evolution and transmission of antibiotic resistance is driven by Beijing lineage Mycobacterium tuberculosis in Vietnam.
Microbiology spectrum - 12 Dec 2023
Silcocks Matthew, Chang Xuling, Thuong Thuong Nguyen Thuy, Qin Youwen, Minh Ha Dang Thi, Khac Thai Phan Vuong, Vijay Srinivasan, Anh Thu Do Dang, Ngoc Ha Vu Thi, Ngoc Nhung Hoang, Huu Lan Nguyen, Quynh Nhu Nguyen Thi, Edwards David, Nath Artika, Pham Kym, Duc Bang Nguyen, Hong Chau Tran Thi, Thwaites Guy, Heemskerk A Dorothee, Chuen Khor Chiea, Teo Yik Ying, Inouye Michael, Ong Rick Twee-Hee, Caws Maxine, Holt Kathryn E, Dunstan Sarah J
Abstract excerpt
IMPORTANCE: Drug-resistant tuberculosis (TB) infection is a growing and potent concern, and combating it will be necessary to achieve the WHO's goal of a 95% reduction in TB deaths by 2035. While prior studies have explored the evolution and spread of drug resistance, we still lack a clear understanding of the fitness costs (if any) imposed by resistance-conferring mutations and the role that Mtb genetic lineage...
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