Article
Validation of a Molecular Diagnostic Test for Circulating Tumor DNA by Next-Gen Sequencing.
International journal of molecular sciences - 30 Oct 2023
Fernandez Sandra V, Tan Yin Fei, Rao Shilpa, Fittipaldi Patricia, Sheriff Fathima, Borghaei Hossein, Dotan Efrat, Winn Jennifer S, Edelman Martin J, Treat Joseph, Judd Julia, Alpaugh R Katherine, Wang Y Lynn, Yu Jian Q, Wasik Mariusz, Baldwin Don A
Abstract excerpt
A modified version of the PGDx elioTM Plasma Resolve assay was validated as a laboratory-developed test (LDT) for clinical use in the Molecular Diagnostics Laboratory at Fox Chase Cancer Center. The test detects single nucleotide variants (SNVs) and small insertions and deletions (indels) in 33 target genes using fragmented genomic DNA extracted from plasma. The analytical performance of this assay was assessed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.