Immunogenicity and protective efficacy of a recombinant adenovirus containing the fusion protein of bovine parainfluenza virus type 3 genotype C in mice.

doi:10.1016/j.micpath.2023.106444

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Article

Immunogenicity and protective efficacy of a recombinant adenovirus containing the fusion protein of bovine parainfluenza virus type 3 genotype C in mice.

Microbial pathogenesis - 1 Dec 2023

Zhang Jiaqi, Zeng Jiangyong, Yuan Zhenjie, Huang Xiangyue, Wu Jinbo, Yu Qisheng, Chen Taoyun, Den Gunan, Zhu Chenxi, Zhang Bin

Abstract excerpt

Bovine parainfluenza virus type 3 (BPIV3) is a viral respiratory pathogen of cattle that causes substantial economic losses. A replicating-defective recombinant human adenovirus type 5 (HAd5), carrying a fusion protein of BPIV3 genotype C (HAd5-F), was constructed and evaluated for its immunogenicity and protective efficacy in mice. After intramuscular injection with the HAd5-F, the IgG titers against F proteins...

Topics

Antibodies, Viral
Adenoviridae
Adenoviruses, Human
Recombinant Proteins
Cattle
Parainfluenza Virus 3, Human
Humans
Genotype
Animals
Parainfluenza Virus 3, Bovine
Mice

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Identifiers

PMID: 37951410
DOI: 10.1016/j.micpath.2023.106444

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