Article
Extracellular vesicles derived from endothelial cells modulate macrophage phenotype in vitro.
European journal of medical research - 9 Nov 2023
He Zhizhen, Greven Johannes, Shi Yulong, Qin Kang, Zhao Qun, Zhang Xing, Buhl Eva Miriam, Eschweiler Jörg, Hildebrand Frank, Balmayor Elizabeth Rosado
Abstract excerpt
Extracellular vesicles (EVs) mediate cell-to-cell communication by horizontally transferring biological materials from host cells to target cells. During exposure to pathogens, pathogen-associated molecular patterns (e.g., lipopolysaccharide, LPS) get in contact with endothelial cells and stimulate the secretion of endothelial cell-derived EVs (E-EVs). The triggered EVs secretion is known to have a modulating...
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