Article
Underlying mechanism of atrial fibrillation-associated Nppa-I137T mutation and cardiac effect of potential drug therapy.
Heart rhythm - 1 Feb 2024
Huang Yan, Wang Ling-Ling, Liu Zhe-Bo, Chen Cheng, Ren Xiang, Luo An-Tao, Ma Ji-Hua, Antzelevitch Charles, Barajas-Martínez Hector, Hu Dan
Abstract excerpt
BACKGROUND: More than a hundred genetic loci have been associated with atrial fibrillation (AF). But the exact mechanism remains unclear and the treatment needs to be improved. OBJECTIVE: This study aimed to investigate the mechanism and potential treatment of NPPA mutation-associated AF. METHODS: Nppa knock-in (KI, p.I137T) rats were generated, and cardiac function was evaluated. Blood pressure was recorded...
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