Article
Mutation and clinical analysis of the CLCC1 gene in amyotrophic lateral sclerosis patients from Central South China.
Annals of clinical and translational neurology - 1 Jan 2024
Tang Linxin, Tang Xuxiong, Zhao Qianqian, Li Yongchao, Bu Yue, Liu Zhen, Li Jinchen, Guo Jifeng, Shen Lu, Jiang Hong, Tang Beisha, Xu Renshi, Cao Wenfeng, Yuan Yanchun, Wang Junling
Abstract excerpt
INTRODUCTION: Recently, chloride channel CLIC-like 1 (CLCC1) was reported to be a novel ALS-related gene. We aimed to screen CLCC1 variants in our ALS cohort and further explore the genotype-phenotype correlation of CLCC1-related ALS. METHODS: We screened rare damaging variants in CLCC1 from our cohorts of 1005 ALS patients and 1224 healthy controls with whole-exome sequencing in Central South China. Fisher's...
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