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Article

Identifying genetic determinants of Streptococcus pyogenes-host interactions in a murine intact skin infection model

25 Oct 2023

Abstract excerpt

Streptococcus pyogenes is an obligate human pathobiont associated with many disease states. Here, we present a model of S. pyogenes infection using intact murine epithelium. We were able to perform RNA sequencing to evaluate genetic changes undertaken by both the bacterium and host at 5 and 24 h post-infection. Analysis of these genomic data demonstrate that S. pyogenes undergoes genetic adaptation to...

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PMID: 37889753
DOI: 10.1016/j.celrep.2023.113332

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