Article
Molecular characteristic analysis of single-nucleotide polymorphisms in SLC16A9/hMCT9.
Life sciences - 1 Dec 2023
Yamaguchi Atsushi, Mukai Yuto, Sakuma Tomoya, Suganuma Yudai, Furugen Ayako, Narumi Katsuya, Kobayashi Masaki
Abstract excerpt
AIMS: Human monocarboxylate transporter 9 (hMCT9), encoded by SLC16A9, is a transporter that mediates creatine transport across the transmembrane. Previously, we reported that hMCT9 is an extracellular pH- and Na+-sensitive creatine transporter with two kinetic components. Recently, some variants of hMCT9 have been found to be associated with serum uric acid levels, hyperuricemia, and gout. Among these, two...
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