Article
Genome-wide association study in 404,302 individuals identifies 7 significant loci for reaction time variability.
Molecular psychiatry - 1 Sept 2023
Wootton Olivia, Shadrin Alexey A, Mohn Christine, Susser Ezra, Ramesar Raj, Gur Ruben C, Andreassen Ole A, Stein Dan J, Dalvie Shareefa
Abstract excerpt
Reaction time variability (RTV), reflecting fluctuations in response time on cognitive tasks, has been proposed as an endophenotype for many neuropsychiatric disorders. There have been no large-scale genome-wide association studies (GWAS) of RTV and little is known about its genetic underpinnings. Here, we used data from the UK Biobank to conduct a GWAS of RTV in participants of white British ancestry...
Topics
- Humans
- Genome-Wide Association Study
- Reaction Time
- Genetic Predisposition to Disease
- Schizophrenia
- Multifactorial Inheritance
- Polymorphism, Single Nucleotide