Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months.

doi:10.1017/S0954579416000560

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Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months.

Development and psychopathology - 1 Aug 2017

Green Cathryn Gordon, Babineau Vanessa, Jolicoeur-Martineau Alexia, Bouvette-Turcot Andrée-Anne, Minde Klaus, Sassi Roberto, St-André Martin, Carrey Normand, Atkinson Leslie, Kennedy James L, Steiner Meir, Lydon John, Gaudreau Helene, Burack Jacob A, Levitan Robert, Meaney Michael J, Wazana Ashley

Abstract excerpt

Prenatal maternal depression and a multilocus genetic profile of two susceptibility genes implicated in the stress response were examined in an interaction model predicting negative emotionality in the first 3 years. In 179 mother-infant dyads from the Maternal Adversity, Vulnerability, and Neurodevelopment cohort, prenatal depression (Center for Epidemiologic Studies Depressions Scale) was assessed at 24 to 36...

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PMID: 27427178
DOI: 10.1017/S0954579416000560
PMCID: PMC5511040

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DRD4

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