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Article

Obesity Characteristics Are Poor Predictors of Genetic Mutations Associated with Obesity

7 Oct 2023

Abstract excerpt

Background: The genetic contribution to obesity is substantial and may underpin the altered pathophysiology. One such pathway involves melanocortin signaling in the hypothalamus. Genetic variants can cause dysregulation in the central melanocortin pathway that can result in early onset of hyperphagia and obesity. Clinically identifying patients who are at risk of known genetic mutations is challenging. The main...

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PMID: 37835041
DOI: 10.3390/jcm12196396

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