Concurrent Targeting of HDAC and PI3K to Overcome Phenotypic Heterogeneity of Castration-resistant and Neuroendocrine Prostate Cancers.

doi:10.1158/2767-9764.CRC-23-0250

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Article

Concurrent Targeting of HDAC and PI3K to Overcome Phenotypic Heterogeneity of Castration-resistant and Neuroendocrine Prostate Cancers.

Cancer research communications - 20 Nov 2023

Zhang Ailin, Lau Nathan A, Wong Alicia, Brown Lisha G, Coleman Ilsa M, De Sarkar Navonil, Li Dapei, DeLucia Diana C, Labrecque Mark P, Nguyen Holly M, Conner Jennifer L, Dumpit Ruth F, True Lawrence D, Lin Daniel W, Corey Eva, Alumkal Joshi J, Nelson Peter S, Morrissey Colm, Lee John K

Abstract excerpt

Castration-resistant prostate cancer (CRPC) consists of multiple phenotypic subtypes including androgen receptor (AR)-active prostate cancer (ARPC) and neuroendocrine prostate cancer (NEPC). Tumor cells with these phenotypes can coexist between metastases within a patient and within an individual tumor. Treatments that are effective across CRPC subtypes are currently lacking. Histone deacetylation is crucial for...

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PMID: 37823778
DOI: 10.1158/2767-9764.CRC-23-0250
PMCID: PMC10658857

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