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SARS-CoV-2 mRNA vaccine requires signal peptide to induce antibody responses

9 Oct 2023

Abstract excerpt

New SARS-CoV-2 variants continue to prevail worldwide, and effective vaccines are needed to prevent an epidemic. mRNA vaccines are gradually being applied to the prevention and control of infectious diseases with significant safety and effectiveness. The spike (S) protein of SARS-CoV-2 is the main target of mRNA vaccine design, but the impact of the signal peptide (SP), transmembrane region (TM), and cytoplasmic...

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PMID: 37821314
DOI: 10.1016/j.vaccine.2023.09.059

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