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CD4 and CD8 T lymphocyte interplay in controlling tumor growth

14 Oct 2017

Abstract excerpt

The outstanding clinical success of immune checkpoint blockade has revived the interest in underlying mechanisms of the immune system that are capable of eliminating tumors even in advanced stages. In this scenario, CD4 and CD8 T cell responses are part of the cancer immune cycle and both populations significantly influence the clinical outcome. In general, the immune system has evolved several mechanisms to...

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PMID: 29032503
DOI: 10.1007/s00018-017-2686-7

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