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Chimpanzee adenovirus-mediated multiple gene therapy for age-related macular degeneration

15 Sept 2023

Abstract excerpt

Neovascular age-related macular degeneration AMD (nAMD) is characterized by choroidal neovascularization (CNV) and could lead to irreversible blindness. However, anti-vascular endothelial growth factor (VEGF) therapy has limited efficacy. Therefore, we generated a chimpanzee adenoviral vector (AdC68-PFC) containing three genes, pigment endothelial-derived factor (PEDF), soluble fms-like tyrosine kinase-1...

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PMID: 37810255
DOI: 10.1016/j.isci.2023.107939

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