Article
Salmonella Derby adaptation to swine and simultaneous attenuation for humans go through decay of Salmonella Pathogenicity Island I.
Microbiology spectrum - 12 Dec 2023
Berni Melissa, Bolzoni Luca, Menozzi Ilaria, Dodi Alessandra, Bracchi Chiara, Morganti Marina, Scaltriti Erika, Pongolini Stefano, Tambassi Martina
Abstract excerpt
IMPORTANCE: This study integrated population data with in vitro assessment of virulence phenotypes to unveil that a considerable part of the global population of Salmonella Derby is evolving to enhance its host adaptation to the swine host and that this evolution is simultaneously increasing its attenuation for humans. The study shows that the fixation of deleterious mutations in SPI-1 has a role in this process....
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