Article
Identification and validation of obesity related genes signature based on microenvironment phenotypes in prostate adenocarcinoma.
Aging - 2 Oct 2023
Liang Linghui, Shang Jinwei, Zhang Yuwei, Xu Yuxin, Zhouteng Yihui, Wen Jianxiang, Zhao Yuxin, Feng Ninghan, Zhao Ruizhe
Abstract excerpt
BACKGROUND: The role of obesity related genes (ORGs) in the immune checkpoint inhibitors (ICIs) treatment of prostate adenocarcinoma (PRAD) has not yet been proved by research. METHODS: We comprehensively evaluated the ORGs patterns in PRAD based on tumor microenvironment (TME) phenotypes and immunotherapy efficacies. Then we constructed a ORGs risk score for prognosis and a ORGs signature for accurate prediction...
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