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Creating an HLA-homozygous iPS cell bank for the Brazilian population: Challenges and opportunities.

Stem cell reports - 10 Oct 2023

Martins de Oliveira Marcio Lassance, Tura Bernardo Rangel, Meira Leite Mauro, Melo Dos Santos Eduardo José, Pôrto Luís Cristóvão, Pereira Lygia V, Campos de Carvalho Antonio Carlos

Abstract excerpt

Identifying human leukocyte antigen (HLA) haplotype-homozygous donors for the generation of induced pluripotent stem (iPS) cell lines permits the construction of biobanks immunologically compatible with significant numbers of individuals for use in therapy. However, two questions must be addressed to create such a bank: how many cell lines are necessary to match most of the recipient population and how many...

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Identifiers

PMID: 37774702
DOI: 10.1016/j.stemcr.2023.09.001
PMCID: PMC10656352

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