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Article

A transcriptional network required for bradyzoite development in Toxoplasma gondii is dispensable for recrudescent disease

28 Sept 2023

Abstract excerpt

Identification of regulators of Toxoplasma gondii bradyzoite development and cyst formation is the most direct way to address the importance of parasite development in long-term persistence and reactivation of this parasite. Here we show that a T. gondii gene (named Regulator of Cystogenesis 1; ROCY1) is sufficient for T. gondii bradyzoite formation in vitro and in vivo. ROCY1 encodes an RNA binding protein that...

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PMID: 37770433
DOI: 10.1038/s41467-023-40948-w

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