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HLA-B*57:01 typing in a Malaysian cohort: implications of abacavir hypersensitivity in people living with HIV.

Pharmacogenomics - 1 Sept 2023

Kalidasan V, Kunalan Iswarya, Rajasuriar Reena, Subbiah Vijay Kumar, Das Kumitaa Theva

Abstract excerpt

Background: Abacavir (ABC) in combination with other antiretroviral drugs, is used to treat people living with HIV (PLWH). However, it is linked to a fatal hypersensitivity reaction in susceptible individuals, and is strongly associated with the HLA-B*57:01 allele. Materials & methods: A total of 152 patients, 50 PLWH and 102 HIV-1 negative patients, were assessed for the HLA-B*57:01 allele through a...

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Alleles
Anti-HIV Agents
Cohort Studies
Dideoxynucleosides
Drug Hypersensitivity

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PMID: 37767641
DOI: 10.2217/pgs-2023-0136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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