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Article

Tumor Mutation Burden-Related Histopathologic Features for Predicting Overall Survival in Gliomas Using Graph Deep Learning.

The American journal of pathology - 1 Dec 2023

Sun Caixia, Luo Tao, Liu Zhenyu, Ge Jia, Shao Lizhi, Liu Xiangyu, Li Bao, Zhang Song, Qiu Qi, Wei Wei, Wang Shuo, Bian Xiu-Wu, Tian Jie

Abstract excerpt

Tumor mutation burden (TMB) is a potential biomarker for evaluating the prognosis and response to immune checkpoint inhibitors, but its costly and time-consuming method of measurement limits its widespread application. This study aimed to identify the TMB-related histopathologic features from hematoxylin and eosin slides and explore their prognostic value in gliomas. TMB-related features were detected using a...

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PMID: 37741452
DOI: 10.1016/j.ajpath.2023.08.015

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