Article
BRCAness of brain lesions reflects a worse outcome for patients with metastatic breast cancer.
Breast cancer research and treatment - 1 Jan 2024
Ishizuka Yumiko, Horimoto Yoshiya, Eguchi Hidetaka, Murakami Fumi, Nakai Katsuya, Onagi Hiroko, Hayashi Takuo, Ishikawa Takashi, Arai Masami, Watanabe Junichiro
Abstract excerpt
PURPOSE: Breast cancer often metastasizes to the central nervous system. Although the prognosis of brain metastases from breast cancer has been considered poor, and systemic therapy has not contributed to an improved prognosis, newer agents are expected to be more effective. BRCAness is defined as the status of homologous recombination deficiency (HRD) in tumor tissue, regardless of the presence of pathogenic...
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