Article
Juvenile Idiopathic Arthritis With Associated Inflammatory Bowel Disease and CARD8 Mutation.
Pediatrics - 1 Oct 2023
Gennaro Victoria L, Maclin Jeanine, Weiser Peter, Stoll Matthew L, Smitherman Emily A
Abstract excerpt
Juvenile idiopathic arthritis is a common chronic childhood disease, with a prevalence of ∼1 per 1000 children. Arthritis can also be a manifestation of other inflammatory conditions, such as inflammatory bowel disease (IBD). Studies suggest a genetic influence in IBD, including mutations in CARD8. CARD8 is a negative regulator of the NLRP3 inflammasome, and mutations in this gene are hypothesized to induce...
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