Association of thyroid peroxidase antibody with the RNF213 p.R4810K variant in ischemic stroke/transient ischemic attack.

doi:10.1016/j.atherosclerosis.2023.117281

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Article

Association of thyroid peroxidase antibody with the RNF213 p.R4810K variant in ischemic stroke/transient ischemic attack.

Atherosclerosis - 1 Oct 2023

Yoshimoto Takeshi, Ishiyama Hiroyuki, Hattori Yorito, Nishimura Kunihiro, Okada Yoko, Watanabe Hideaki, Ohyagi Yasumasa, Akaiwa Yasuhisa, Miyamoto Tomoyuki, Kawamoto Michi, Ichijo Masahiko, Inoue Hiroyasu, Matsukawa Noriyuki, Mizuno Toshiki, Matsuyama Hirofumi, Tomimoto Hidekazu, Kawakami Daisuke, Toyoda Kazunori, Koga Masatoshi, Ihara Masafumi

Abstract excerpt

BACKGROUND AND AIMS: RNF213 is a susceptibility gene for moyamoya disease and vasospastic angina, with a second hit considered necessary for their development. Elevated thyroid peroxidase antibody (TPO-Ab) levels have been observed in both diseases, suggesting a possible role of TPO-Ab as a second hit for developing RNF213-related vasculopathy. We investigated the association of TPO-Ab levels with RNF213-related...

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Identifiers

PMID: 37722316
DOI: 10.1016/j.atherosclerosis.2023.117281

Genes

RNF213
TPO

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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